Botulinum toxin and refractory non-neurogenic overactive detrusor.
Identifieur interne : 000088 ( Main/Exploration ); précédent : 000087; suivant : 000089Botulinum toxin and refractory non-neurogenic overactive detrusor.
Auteurs : I. Ksibi [Tunisie] ; A-L Godard ; P. Azouvi ; P. Denys ; C. DziriSource :
- Annals of physical and rehabilitation medicine [ 1877-0665 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Vessie hyperactive.
- usage thérapeutique : Agents neuromusculaires, Toxines botuliniques.
- Humains, Qualité de vie, Urodynamique.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Neuromuscular Agents.
- drug therapy : Urinary Bladder, Overactive.
- Humans, Quality of Life, Urodynamics.
Abstract
PURPOSE
To study the value and efficacy of botulinum toxin for treatment of cases of non-neurogenic detrusor overactivity (NNDO) that are refractory to anticholinergic drugs.
MATERIALS AND METHODS
A systematic review of the literature, based on a keyword search of the Medline database. Selection of articles in French and English (meta-analyses, reviews, case studies and randomized, controlled clinical trials) on intradetrusor botulinum toxin injection in the management of refractory NNDO.
RESULTS
Nineteen publications (including three randomized, controlled trials) were selected. Intradetrusor injection of botulinum toxin in patients with refractory NNDO has produced promising results, with a significant improvement in physical symptoms, urodynamic parameters and quality of life. The rare side effects consist primarily of dose-dependent urine retention.
CONCLUSION
On the basis of preliminary data, botulinum toxin appears to be a valuable therapeutic option and fills the gap between anticholinergics and surgery in the treatment of NNDO that is refractory to anticholinergic agents. Botulinum toxin has a promising future in urology but requires further scientific evaluation.
DOI: 10.1016/j.rehab.2009.07.032
PubMed: 19729357
Affiliations:
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Le document en format XML
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Denys</name></author><author><name sortKey="Dziri, C" sort="Dziri, C" uniqKey="Dziri C" first="C" last="Dziri">C. Dziri</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19729357</idno><idno type="pmid">19729357</idno><idno type="doi">10.1016/j.rehab.2009.07.032</idno><idno type="wicri:Area/PubMed/Corpus">000730</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000730</idno><idno type="wicri:Area/PubMed/Curation">000726</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000726</idno><idno type="wicri:Area/PubMed/Checkpoint">000747</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000747</idno><idno type="wicri:Area/Main/Merge">000088</idno><idno type="wicri:Area/Main/Curation">000088</idno><idno type="wicri:Area/Main/Exploration">000088</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Botulinum toxin and refractory non-neurogenic overactive detrusor.</title><author><name sortKey="Ksibi, I" sort="Ksibi, I" uniqKey="Ksibi I" first="I" last="Ksibi">I. Ksibi</name><affiliation wicri:level="1"><nlm:affiliation>institut national d'orthopédie Mohamed Kassab, La Manouba, Tunisia. imeneksibi@yahoo.fr</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>institut national d'orthopédie Mohamed Kassab, La Manouba</wicri:regionArea><wicri:noRegion>La Manouba</wicri:noRegion></affiliation></author><author><name sortKey="Godard, A L" sort="Godard, A L" uniqKey="Godard A" first="A-L" last="Godard">A-L Godard</name></author><author><name sortKey="Azouvi, P" sort="Azouvi, P" uniqKey="Azouvi P" first="P" last="Azouvi">P. Azouvi</name></author><author><name sortKey="Denys, P" sort="Denys, P" uniqKey="Denys P" first="P" last="Denys">P. Denys</name></author><author><name sortKey="Dziri, C" sort="Dziri, C" uniqKey="Dziri C" first="C" last="Dziri">C. Dziri</name></author></analytic><series><title level="j">Annals of physical and rehabilitation medicine</title><idno type="eISSN">1877-0665</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Botulinum Toxins (therapeutic use)</term><term>Humans (MeSH)</term><term>Neuromuscular Agents (therapeutic use)</term><term>Quality of Life (MeSH)</term><term>Urinary Bladder, Overactive (drug therapy)</term><term>Urodynamics (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents neuromusculaires (usage thérapeutique)</term><term>Humains (MeSH)</term><term>Qualité de vie (MeSH)</term><term>Toxines botuliniques (usage thérapeutique)</term><term>Urodynamique (MeSH)</term><term>Vessie hyperactive (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Urinary Bladder, Overactive</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Vessie hyperactive</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents neuromusculaires</term><term>Toxines botuliniques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Quality of Life</term><term>Urodynamics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Qualité de vie</term><term>Urodynamique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b></p><p>To study the value and efficacy of botulinum toxin for treatment of cases of non-neurogenic detrusor overactivity (NNDO) that are refractory to anticholinergic drugs.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b></p><p>A systematic review of the literature, based on a keyword search of the Medline database. Selection of articles in French and English (meta-analyses, reviews, case studies and randomized, controlled clinical trials) on intradetrusor botulinum toxin injection in the management of refractory NNDO.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Nineteen publications (including three randomized, controlled trials) were selected. Intradetrusor injection of botulinum toxin in patients with refractory NNDO has produced promising results, with a significant improvement in physical symptoms, urodynamic parameters and quality of life. The rare side effects consist primarily of dose-dependent urine retention.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>On the basis of preliminary data, botulinum toxin appears to be a valuable therapeutic option and fills the gap between anticholinergics and surgery in the treatment of NNDO that is refractory to anticholinergic agents. Botulinum toxin has a promising future in urology but requires further scientific evaluation.</p></div></front></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Azouvi, P" sort="Azouvi, P" uniqKey="Azouvi P" first="P" last="Azouvi">P. Azouvi</name><name sortKey="Denys, P" sort="Denys, P" uniqKey="Denys P" first="P" last="Denys">P. Denys</name><name sortKey="Dziri, C" sort="Dziri, C" uniqKey="Dziri C" first="C" last="Dziri">C. Dziri</name><name sortKey="Godard, A L" sort="Godard, A L" uniqKey="Godard A" first="A-L" last="Godard">A-L Godard</name></noCountry><country name="Tunisie"><noRegion><name sortKey="Ksibi, I" sort="Ksibi, I" uniqKey="Ksibi I" first="I" last="Ksibi">I. Ksibi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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